Objective
To investigate
the tablet friability
Apparatus and Chemical
Friabilator, Weighing
boat, Weighing balance, Ettrocin tablet
Procedure
1. 10
Ettrocin tablets were selected and weighed.
2. All
tablets were put into the drum of the friabilator. The rate of rotation and
time were set to 100 rpm and 10 minutes. The operation was started then.
3. All
the tablets were removed at the end of the operation. The tablets were free
from dust or powder.
4. The
tablets were reweighed. The percentage loss of weight was determined.
Results
Tablet
used: Ettrocin 250 mg Film Coated Tablet
Initial
weight of 10 tablets: 6.5777 g
Final
weight of 10 tablets: 6.5270 g
Calculations
Loss
of weight = 6.5777
g – 6.5270 g
= 0.0507 g
Percentage
loss of weight =
x 100%
=
0.771 %
Discussion
Friability refers the ability of the
compressed tablet to avoid fracture and breaking during transportation process.
In friability test, the tablets are prone to
abrasion hence enabling us to check for the tablet strength by tumbling them in
a rotating drum.
In
this experiment, 10 tablets of 250mg Ettrocin were selected and weighed before
it was put into drum of the friabilator. The speed for the rate of rotation is
25 rpm and it was done for 10 minutes. The loss of the weight due to abrasion was
measured by comparing the initial weight of the tablets with the final weight
of the tablets. Then, the percentage loss of weight of the tablets was calculated.
The higher the amount of weight loss, the more fragile are the tablets.
Based on the result, the percentage loss
of weight of 10 tablets of Ettrocin is 0.771%. Therefore, Ettrocin tablets that
lose less than 0.5% to 1% of weight are considered acceptable and can have the
ability to withstand the abrasion during packaging and shipping.
There was a minor error during the
experiment. The drum of the friabilator are not placed properly and dropped
down during the operation and we afraid might affected the result. However,
after calculation was made, percentage loss of weight of tablets was still in
the acceptable range. This means, those tablets are strong tablets which then
can endure the stresses.
Conclusion
The Ettrocin tablets has a
percentage loss of weight of 0.771% which is less than 1%. So, we can conclude
that the tablets are strong and hard enough to prevent breaking during the packing,
handling and also shipping and suitable for commercial use. It also can be
conclude that our experiment run successfully.
References
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