Objective
To determine the
uniformity of weight of tablets and capsules that comply with the standard of
British Pharmacopoiea.
TABLETS
(PARALGIN)
Apparatus
And Materials
-
Weighing boat - Weighing balance
-
Paralgin tablet
Procedure
1. 20 tablets previously selected at
random were weighed. The average weight was determined.
2.
The
tablets were weighed individually and for each tablet , the percentage
deviation of its weight from the average weight was determined.
3. The deviation of individual weight
from the average weight should not exceed the limits given below.
Results Of Tablet
Tablet
|
Weight(G)
|
Deviation(%)
|
|
1
|
0.695
|
(total net weight)/20
= 7.7922/20
=0.38916
|
2.206
|
2
|
0.696
|
2.353
|
|
3
|
0.671
|
1.324
|
|
4
|
0.673
|
1.029
|
|
5
|
0.675
|
0.735
|
|
6
|
0.678
|
0.294
|
|
7
|
0.673
|
1.029
|
|
8
|
0.676
|
0.588
|
|
9
|
0.686
|
0.882
|
|
10
|
0.684
|
0.588
|
|
11
|
0.680
|
0
|
|
12
|
0.659
|
3.088
|
|
13
|
0.674
|
0.882
|
|
14
|
0.662
|
2.647
|
|
15
|
0.690
|
1.471
|
|
16
|
0.671
|
1.324
|
|
17
|
0.684
|
0.588
|
|
18
|
0.704
|
3.529
|
|
19
|
0.684
|
0.588
|
|
20
|
0.677
|
0.441
|
CAPSULES (MEFA)
Apparatus And Materials
-
Weighing
boat -
Weighing balance
-
MEFA
capsules
Procedure
1. 20 capsules MEFA were selected.
2. One of the capsules was weight.
Then, the capsule was opened and its contents were removed completely before
next step.
3. Next, the weight of the capsule was
weight and net weight of the contents was determined.
4. The same procedures were repeated
for other 19 capsules.
5. The average net weight was then
determined by sum up all the individual net weights.
6. The percentage deviations of the
capsules’ weight were determined.
7. The deviation of individual net
weight should not exceed the limits given below.
Percentage deviation =
Results Of Capsules
Bil
|
Whole Capsules (G)
|
Emptied Capsules (G)
|
Net
Weight
(G)
|
Average Weight
(G)
|
Percentage Deviation (%)
|
1
|
0.4774
|
0.0801
|
0.3973
|
(total net weight)/20
= 7.7922/20
=0.38916
|
1.97
|
2
|
0.4613
|
0.0775
|
0.3838
|
1.49
|
|
3
|
0.4700
|
0.0741
|
0.3959
|
1.61
|
|
4
|
0.4531
|
0.0727
|
0.3804
|
1.07
|
|
5
|
0.4613
|
0.0737
|
0.3876
|
0.52
|
|
6
|
0.4684
|
0.0752
|
0.3932
|
0.92
|
|
7
|
0.4642
|
0.0764
|
0.3878
|
0.46
|
|
8
|
0.4679
|
0.0733
|
0.3946
|
1.28
|
|
9
|
0.4541
|
0.0806
|
0.3735
|
4.13
|
|
10
|
0.4665
|
0.0767
|
0.3898
|
0.05
|
|
11
|
0.4673
|
0.0725
|
0.3948
|
1.28
|
|
12
|
0.4650
|
0.0803
|
0.3847
|
1.26
|
|
13
|
0.4704
|
0.0753
|
0.3951
|
1.41
|
|
14
|
0.4692
|
0.0731
|
0.3961
|
1.67
|
|
15
|
0.4579
|
0.0717
|
0.3862
|
0.88
|
|
16
|
0.4672
|
0.0731
|
0.3941
|
1.15
|
|
17
|
0.4658
|
0.0717
|
0.3941
|
1.15
|
|
18
|
0.4673
|
0.0785
|
0.3888
|
0.21
|
|
19
|
0.4708
|
0.0799
|
0.3909
|
0.33
|
|
20
|
0.4606
|
0.0771
|
0.3835
|
1.57
|
Discussion
From
the result, it shows that the average weight of the Paralgin tablet is . Therefore,
the percentage deviation of this tablet should has minimum 18 tablets that in
the range of ± 5.0% and maximum 2 tables that in the range of ± 10.0%. From the
calculated data, it shows that all the tablets follow the limits given. 18 of
the tablets are in the range of ± 5.0% and 2 of the tablets are in the range of
± 10.0%. The maximum deviation percentage is -5.5538%. This shows that all
tablets used is our experiment are uniform from the aspect of weight.
The
average weight of MEFA capsule is 0.38961 g (389.61 mg). Therefore, the
percentage deviation of this capsule should has minimum 18 capsules that in the
range of ± 7.5% and maximum 2 capsules that in the range of ± 15.0%. After all
the data have been calculated, it shows that all the capsules follow the limits
given. 20 of the capsules are in the range of ± 7.5% and none of the capsules
are in the range of ± 15.0%. The maximum deviation percentage that we obtained
is 4.13%. This shows that all capsules used is our experiment are uniform from
the aspect of weight.
However,
there might be some error that occur when measuring the weight of these tablets
and capsules. Some powders might still get stuck inside the capsule shells and
the powders are not completely removed. This will cause the weight of the
emptied shell slightly inaccurate. Besides that, errors also might occur due to
the air flow or wind around the weighing balance that will cause the weight
measured slightly inaccurate.
Conclusion
In a conclusion, the objective of this experiment in
study the uniformity of weight of tablets and capsules that comply with the
standard of British Pharmacopoiea is achieved. The experiment conducted is very
useful in the quality control during the production of tablet and capsules.
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